At the annual meeting of the American Society of Clinical Oncology (ASCO), Mayo investigators report that cancer in about two-thirds of 37 patients with aggressive differentiated thyroid cancer treated with the drug pazopanib either stopped growing, or quickly shrank.
The patient responses seen to date are promising, the researchers say, because all patients had fast-growing cancers that had spread to their lungs, with half involving lymph nodes and 39 percent thus involving bones.
"The benefits were striking in many patients to a degree we have not previously seen in thyroid cancer in response to other therapies, including the standard treatment of radioiodine," says Keith Bible, MD, Ph.D., a medical oncologist and researcher who led the multi-center clinical trial funded by the National Cancer Institute. Most of the patients enrolled were treated at the Mayo Clinic campuses in Minnesota and Florida.
Approximately one-third of patients achieved sustained and dramatic benefit from pazopanib, while another one-third experienced stabilization of their cancer or some tumor shrinkage. The remaining one-third of patients did not benefit from the drug. The agent was also well tolerated by the majority of patients, Dr. Bible adds.
What is not yet known, however, is the drug's effect on overall survival. "We need more time to establish definitively that," says Dr. Bible. "The trial has been going on for just over a year, and some of our patients are still maintaining a response, while others have not been in the study long enough for us to confirm duration of response." He notes that 37 of the original trial participants, two have died - one from cancer progression and another from other causes.
The National Cancer Institute estimated that 37.340 new cases of thyroid cancer would be diagnosed in 2008, with 1.590 deaths from the cancer. The cancer is much more common in women, it is the seventh most common cancer in women in the U.S. The occurrence of thyroid cancer has been rising recently.
Most thyroid cancers are of two major "differentiated" types - papillary thyroid cancer (the most common, accounting for 75 percent of cases) and Follicular thyroid cancer (15 percent).
Fortunately, most patients with thyroid cancer respond well to surgery and to follow-up treatment with radioiodine, even if the cancer recurs and spreads, the disease progresses slowly in most patients, Dr. Bible says. "Many patients do well for a long time without the need of additional therapy," he says. However, about 5 percent of these patients experience rapidly progressing life-threatening disease that is insensitive to radioiodine and other treatment approaches. "Until only recently, we have not had any effective therapies for such patients."
Pazopanib is an experimental agent that is also being studied in advanced kidney, Ovarian and other cancers. The drug, administered in pill form, targets proteins involved in Angiogenesis, the growth of new blood vessels that has a critical role in the growth and spread of tumors. The proteins that pazopanib targets include vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), c-Kit and Ret.
Mayo investigators are also leading clinical trials to test pazopanib in two other thyroid cancer subtypes, medullary, which does not respond to radioiodine, and anaplastic, the most aggressive subtype.
Dr. Bible says plans are also under way to test pazopanib in a larger, controlled and randomized clinical trial of patients with advanced differentiated thyroid cancer. Researchers want to more accurately assess benefits and risks.
Tuesday, June 9, 2009
How does the human brain work?
'Nature' journals are synonymous with the very best in research. Earlier this year, an article by University of Leicester professor bioengineer Rodrigo Quian Quiroga, not only appeared in Nature Reviews Neuroscience, but also featured on the magazine cover. In the article, Professor Quian Quiroga and co-author Dr. Stefano Panzeri discuss new methodologies that are enabling scientists to better understand how our brain processes information.
... more about:
> Age-old mystery> Bioengineering> Bird Communication> chemical process> chloride ions> electrochemical processes> human brain> Nature Immunology> nerve cells> neural coding> neural prostheses> neurons> Neuroscience> potassium> sodium
The human brain is perhaps the most complex of organs, Boasting between 50-100 billion nerve cells or neurons that constantly interact with each other. These neurons' carry 'messages through electrochemical processes; meaning, chemicals in our body (charged sodium, potassium and chloride ions) move in and out of these cells and to establish electrical current.
Scientists have, for a long time now, stimulated with different types of inputs individual neurons that have been isolated for study. To have enough statistical power, these experiments typically involved stimulating a single neuron over and over again, to get a general idea of how it responds to different signals. Although these studies have yielded a lot of information, they have their own limitations.
Professor Quian Quiroga, explains, "The human brain typically makes decisions based on a single stimulus, by evaluating the activity of a large number of neurons. I do not get in front of a tiger to make 100 times an average of my neuronal responses and decide if I should run or not. If I see a tiger once, I run ". Traditional studies thus undermine this complexity only by accounting for the responses single neurons.
Moreover, these studies take into account an "average response obtained by stimulating the neuron numerous times. The brain, on the other hand, acts based on single stimulus presentations. Therefore, the information given by an averaged response can often be insufficient.
Prof. Dr. Quian Quiroga and stress Panzeri, on account of these factors "it is important to shift from a single neuron, multiple-trial framework to multiple-neuron, single-trial methodologies." In other words, it is more beneficial to study numerous responses of neurons to a single stimulus.
Professor Quian Quiroga says, "A major challenge of our day is (thus) to develop the methodologies to record and process the data from hundreds of neurons and developing these is by no means a trivial task."
He adds, "Our brains are able to create very complex processes - just imagine the perfect harmony with which we move different muscles for normal walking - thousands of neurons are involved in this and to determine the role of each is complicated."
In his recent review paper, Professor Quian Quiroga and Dr. Panzeri discuss two complementary approaches that can be used to resolve this, namely 'decoding' and 'information theory'.
'Decoding' essentially helps determine what must have caused a particular response (much like the "working backwards"). Thus, the response of a neuronal population is used to reCONSTRUCT the stimulus or behavior that caused it in the first place. 'Information theory', on the other hand, literally quantifier how much information a number of neurons carry about the stimulus.
Professor Quian Quiroga, explains, "Together, the two approaches not only allow scientists to extract more information on how the brain works, but information that is ambiguous at the level of single neurons, can be clearly evaluated when the whole 'population' is considered ". The review is an asset for anyone involved in the field, as it carefully considers and evaluates the two statistical approaches, as well as describes potential applications.
As part of his own research, Professor Quian Quiroga (in collaboration with Prof. Richard Andersen at Caltech) has been studying the 'decoding' of movement plans using activity of certain neuronal populations. This ability to predict intentions from movement activity of neurons has application in brain-machine interfaces, especially for development of neural prostheses (electronic and / or mechanical devices that connect to the nervous system and replace functions lost as a result of disease or injury) for paralysed patients.
Rodrigo Quian Quiroga is a professor in Bioengineering at the University of Leicester. His research interests include several visual perception (how the brain apprehends what our eyes see), memory and neural coding (how information is represented in the brain by neurons). He is actively involved in developing methods that analyze functioning of various neurons. He has published articles in several high-impact journals, including Nature, Nature Reviews Neuroscience, Neuron and the Proceedings of the National Academy of Sciences.
NOTE TO NewsDesk:
Rodrigo Quian Quiroga - Short Biography
Rodrigo Quian Quiroga graduated in physics at the University of Buenos Aires, Argentina, in 1993. After 2 years working at the Department of Physiology in the Institute for Neurological Investigations - FLENI, Argentina, and one further year at the Department of Epilepsy of the same institute, he moved to Germany and obtained his PhD in applied mathematics at the University of Luebeck in 1998. He was a post-doctoral fellow at the Research Center Juelich, Germany, from 1998 to 2001 and from 2001 to 2004 he was a Sloan fellow at the California Institute of Technology, USA. He was appointed as a Lecturer in Bioengineering at the Department of Engineering of the University of Leicester in 2004, was promoted to Reader in 2006 and to a personal chair in 2008.
Professor Quian Quiroga main research focus is on neuroscience and the analysis of electro physiological data. This research involves the use and development of advanced methods of signal processing. In particular, he developed at automatic method for processing the neural data that is currently used by several neurophysiology laboratories. The use of this method allowed the finding of a new type of 'abstract' (eg Jennifer Aniston) neurons in the human brain that was published in Nature, obtained the first prize at an international meeting in Madrid in 2005 and received world-wide media attention, including articles in The New York Times, Scientific American, Daily Mail, New Scientist, The Independent, etc. It has also been selected as one of the top 100 scientific stories of 2005 by Discover Magazine. In 2008, his follow-up work in this line of research was selected as one of the "Breaking news in neuroscience" by the Federation of European Neuroscience Societies (FENS).
Professor Quian Quiroga is a member of the editorial board of 3 international journals. He acts as reviewer for several international journals in the fields of Applied Mathematics, Physics, Signal Analysis, Clinical Neurophysiology and Neuroscience. He has given more than 30 invited lectures in the last 3 years, had published more than 50 refereed journal papers and currently holds 2 EPSRC grants, 1 MRC grant and 1 grant from the Royal Society.
... more about:
> Age-old mystery> Bioengineering> Bird Communication> chemical process> chloride ions> electrochemical processes> human brain> Nature Immunology> nerve cells> neural coding> neural prostheses> neurons> Neuroscience> potassium> sodium
The human brain is perhaps the most complex of organs, Boasting between 50-100 billion nerve cells or neurons that constantly interact with each other. These neurons' carry 'messages through electrochemical processes; meaning, chemicals in our body (charged sodium, potassium and chloride ions) move in and out of these cells and to establish electrical current.
Scientists have, for a long time now, stimulated with different types of inputs individual neurons that have been isolated for study. To have enough statistical power, these experiments typically involved stimulating a single neuron over and over again, to get a general idea of how it responds to different signals. Although these studies have yielded a lot of information, they have their own limitations.
Professor Quian Quiroga, explains, "The human brain typically makes decisions based on a single stimulus, by evaluating the activity of a large number of neurons. I do not get in front of a tiger to make 100 times an average of my neuronal responses and decide if I should run or not. If I see a tiger once, I run ". Traditional studies thus undermine this complexity only by accounting for the responses single neurons.
Moreover, these studies take into account an "average response obtained by stimulating the neuron numerous times. The brain, on the other hand, acts based on single stimulus presentations. Therefore, the information given by an averaged response can often be insufficient.
Prof. Dr. Quian Quiroga and stress Panzeri, on account of these factors "it is important to shift from a single neuron, multiple-trial framework to multiple-neuron, single-trial methodologies." In other words, it is more beneficial to study numerous responses of neurons to a single stimulus.
Professor Quian Quiroga says, "A major challenge of our day is (thus) to develop the methodologies to record and process the data from hundreds of neurons and developing these is by no means a trivial task."
He adds, "Our brains are able to create very complex processes - just imagine the perfect harmony with which we move different muscles for normal walking - thousands of neurons are involved in this and to determine the role of each is complicated."
In his recent review paper, Professor Quian Quiroga and Dr. Panzeri discuss two complementary approaches that can be used to resolve this, namely 'decoding' and 'information theory'.
'Decoding' essentially helps determine what must have caused a particular response (much like the "working backwards"). Thus, the response of a neuronal population is used to reCONSTRUCT the stimulus or behavior that caused it in the first place. 'Information theory', on the other hand, literally quantifier how much information a number of neurons carry about the stimulus.
Professor Quian Quiroga, explains, "Together, the two approaches not only allow scientists to extract more information on how the brain works, but information that is ambiguous at the level of single neurons, can be clearly evaluated when the whole 'population' is considered ". The review is an asset for anyone involved in the field, as it carefully considers and evaluates the two statistical approaches, as well as describes potential applications.
As part of his own research, Professor Quian Quiroga (in collaboration with Prof. Richard Andersen at Caltech) has been studying the 'decoding' of movement plans using activity of certain neuronal populations. This ability to predict intentions from movement activity of neurons has application in brain-machine interfaces, especially for development of neural prostheses (electronic and / or mechanical devices that connect to the nervous system and replace functions lost as a result of disease or injury) for paralysed patients.
Rodrigo Quian Quiroga is a professor in Bioengineering at the University of Leicester. His research interests include several visual perception (how the brain apprehends what our eyes see), memory and neural coding (how information is represented in the brain by neurons). He is actively involved in developing methods that analyze functioning of various neurons. He has published articles in several high-impact journals, including Nature, Nature Reviews Neuroscience, Neuron and the Proceedings of the National Academy of Sciences.
NOTE TO NewsDesk:
Rodrigo Quian Quiroga - Short Biography
Rodrigo Quian Quiroga graduated in physics at the University of Buenos Aires, Argentina, in 1993. After 2 years working at the Department of Physiology in the Institute for Neurological Investigations - FLENI, Argentina, and one further year at the Department of Epilepsy of the same institute, he moved to Germany and obtained his PhD in applied mathematics at the University of Luebeck in 1998. He was a post-doctoral fellow at the Research Center Juelich, Germany, from 1998 to 2001 and from 2001 to 2004 he was a Sloan fellow at the California Institute of Technology, USA. He was appointed as a Lecturer in Bioengineering at the Department of Engineering of the University of Leicester in 2004, was promoted to Reader in 2006 and to a personal chair in 2008.
Professor Quian Quiroga main research focus is on neuroscience and the analysis of electro physiological data. This research involves the use and development of advanced methods of signal processing. In particular, he developed at automatic method for processing the neural data that is currently used by several neurophysiology laboratories. The use of this method allowed the finding of a new type of 'abstract' (eg Jennifer Aniston) neurons in the human brain that was published in Nature, obtained the first prize at an international meeting in Madrid in 2005 and received world-wide media attention, including articles in The New York Times, Scientific American, Daily Mail, New Scientist, The Independent, etc. It has also been selected as one of the top 100 scientific stories of 2005 by Discover Magazine. In 2008, his follow-up work in this line of research was selected as one of the "Breaking news in neuroscience" by the Federation of European Neuroscience Societies (FENS).
Professor Quian Quiroga is a member of the editorial board of 3 international journals. He acts as reviewer for several international journals in the fields of Applied Mathematics, Physics, Signal Analysis, Clinical Neurophysiology and Neuroscience. He has given more than 30 invited lectures in the last 3 years, had published more than 50 refereed journal papers and currently holds 2 EPSRC grants, 1 MRC grant and 1 grant from the Royal Society.
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